Disorders of autonomic function |
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HYPOTHALAMIC AND BRAIN STEM DISORDERS: Because the hypothalamus is small, lesions of this regulatory station of autonomic function usually involve several nuclei and pathways. Therefore even small lesions can produce a variety of symptoms, depending on the specific area or areas damaged. Thus the following disorders may occur in various combinations following damage to the hypothalamus: Impaired homeothermy : Hyperthermia, from the inability to dissipate body heat, is the commonest. Diabetes Insipidus: characterized by:
Sleep Disorders: e.g: narcolepsy, insomnia, hypersomnia, and other changes in the normal sleep rhythm. Feeding disorders: These range from
Growth and Development Disorders: These result from malfunction of the adenohypophysis due to abnormalities in production of trophic factors from the hypothalamus e.g. dwarfism, delayed puberty. Adiposogenital dystrophy (Frohlich's syndrome) is a genetic disorder of hypothalamic function, present from birth. It is characterized by a) obesity, especially around the shoulders, and hips and b) a generalized genital hypoplasia and immaturity. Argyll Robertson's pupil:
Paroxysmal hypertension or orthostatic hypotension: These may result from damage to the lower brain stem vasopressor and vasodepressor centres. Both are often associated with space occupying lesions of the posterior cranial fossa. Familial dysautonomia (Riley-Day Syndrome): This is a rare autosomal recessive disorder. |
PERIPHERAL DISORDERS OF AUTONOMIC FUNCTION: |
Aganglionic megacolon (Hirschsprung's disease): |
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Mydriasis |
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Horner's syndrome |
This results from an interruption of the sympathetic innervation to the head and neck. The interruption of the sympathetic innervation can be due damage to any of the following:
The basic symptoms of the syndrome are as follows:
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